In Save Our Souls 2 to 4 players try to evacuate (reduce to 0 cards) their doomed cruise ships (their deck).
Ever since Dominion and the early adopters of the deckbuilding mechanism had been released, the designer mused about a deck de(con)struction game being released just being a matter of time.
Up to now, nobody has implemented this in a way that uses deckbuilding mechanisms and where the sole goal is to empty the deck (Valley of the Kings being very close though).
Rescue cards from your deck, buy action cards to speed up things, be the first to empty the deck (pun intended).